エムダッシュの台頭：大規模言語モデル時代における医学論文での使用頻度の急増

Large language models (LLMs) can leave subtle stylistic traces in assisted text; one of the most cited is the em-dash (Unicode U+2014). Yet no one has measured whether em-dash use has changed in the scientific literature. This study, pre-registered on the Open Science Framework (HFT8C), used the full set of medRxiv full-text XML preprints from the official Text-and-Data-Mining resource. The primary cohort was first, original versions deposited 2020-2025 with an extractable Discussion section of at least 500 characters (N = 69,632). The primary endpoint was the presence of at least one em-dash in the Discussion; the principal measure was the absolute change in its prevalence between the pre-ChatGPT era (before 30 November 2022) and the post-ChatGPT era, estimated with a logistic model with standard errors clustered by first author. The analysis plan (six supporting analyses, six sensitivity analyses, two falsification tests) was frozen before any confirmatory result was computed. Em-dash prevalence in Discussion sections rose from 4.23% before ChatGPT to 11.58% afterward, an absolute increase of 7.35 percentage points (95% CI 6.94-7.77; odds ratio 2.96, 95% CI 2.77-3.17). The rise was not a sharp jump but a gradual, delayed acceleration: near 4% through 2023, 8.0% in 2024, and 20.3% in 2025. The effect survived every feasible sensitivity analysis (7.35-7.60 pp) and both falsification tests; a placebo split within the pre-LLM era showed no meaningful change (+0.13 pp, 95% CI -0.33 to +0.58), and was essentially absent in boilerplate sections. Independent LLM-associated lexical markers and within-paper section comparisons pointed the same way. The em-dash is a population-level indicator, not a per-paper detector of LLM use, and the design cannot establish causality; it shows that something in how scientific literature is written changed markedly in the early 2020s, and roughly when.